Dimethyl Sulfoxide
Apexbio Technology LLC Dorsomorphin 2HCl 1219168-18-9 10mM (in 1mL DMSO)
Dorsomorphin 2HCl (CAS 1219168-18-9) is a small-molecule inhibitor targeting BMP signaling through selective blockade of BMP type I receptors ALK2 ALK3 and ALK6 It prevents phosphorylation of downstream effectors SMAD1/5/8 with an IC50 of approximately 0 47 mM Originally identified by zebrafish phenotypic screening as a disruptor of embryonic dorsoventral patterning Dorsomorphin has been employed to dissect BMP-regulated pathways in iron homeostasis significantly affecting hepcidin expression and iron metabolism in vitro and in vivo It is widely utilized in mechanistic studies of BMP function and signaling regulation
Apexbio Technology LLC Flutamide 13311-84-7 10mM (in 1mL DMSO)
Flutamide is a synthetic nonsteroidal antiandrogen agent commonly employed in biomedical research and clinical oncology Its pharmacological activity is mediated through competitive antagonism at the androgen receptor (AR) whereby its active metabolite interacts specifically with AR exhibiting a receptor binding affinity at a K sub i /sub value around 55 nM By interfering with androgen signaling pathways flutamide inhibits AR-mediated transcriptional activity resulting in reduced cellular proliferation particularly in androgen-dependent tissues In research contexts this compound is frequently utilized to investigate AR-mediated cell biology androgen-dependent tumor development and as a pharmacological tool in model systems studying prostate cancer biology and therapeutic resistance mechanisms
Apexbio Technology LLC CUDC-907 1339928-25-4 10mM (in 1mL DMSO)
CUDC-907 (CAS 1339928-25-4) is a dual inhibitor targeting histone deacetylases (HDACs 1 2 3 10) and class I phosphatidylinositol 3-kinases (PI3K) It exhibits nanomolar inhibitory activity against these enzymes blocking PI3K-mediated Akt signaling and increasing acetylation of histones and non-histone substrates (e g tubulin p53) In cancer cell models CUDC-907 induces G2-M phase arrest and reduces phosphorylation of downstream proteins such as p70S6 4EBP-1 MEK STAT3 and SRC Preclinical studies demonstrate its anti-tumor activity in lymphoma and NSCLC xenografts making it relevant for oncology research
Apexbio Technology LLC PTC-209 315704-66-6 10mM (in 1mL DMSO)
PTC-209 (CAS 315704-66-6) is a small-molecule inhibitor targeting BMI-1 identified through Gene Expression Modulation by Small molecules (GEMS) technology It acts by suppressing BMI-1 expression at the transcriptional level displaying an IC50 of approximately 0 5 M In HCT116 cells PTC-209 reduces both UTR-mediated and endogenous BMI-1 expression It selectively restricts cell proliferation in certain tumor and stem cell types including U937 HT1080 and human hematopoietic stem cells without affecting viability in cell lines such as HEK293 and HT1080 Thus PTC-209 is primarily utilized in studies exploring cancer stem cell growth and oncogenesis involving BMI-1 and the PRC1 complex
Apexbio Technology LLC Moclobemide (Ro 111163) 71320-77-9 10mM (in 1mL DMSO)
Moclobemide (Ro 111163 CAS 71320-77-9) is a reversible inhibitor of monoamine oxidase A (MAO-A) with a reported IC50 of approximately 10 M In vitro studies using rat brain homogenate indicate that it selectively targets MAO-A over MAO-B though with moderate potency Animal experiments demonstrate up to 80% inhibition of MAO-A activity in brain and liver tissues upon administration Prolonged high-dose exposure to Moclobemide alters adrenergic receptor profiles by downregulating -adrenergic receptors and enhancing affinity of 1-adrenergic agonist binding Due to its MAO-A specificity this compound serves as a prototype reversible inhibitor (RIMA) with relevance in antidepressant drug research
Apexbio Technology LLC TWS119 601514-19-6 10mM (in 1mL DMSO)
TWS119 (CAS 601514-19-6) is a selective inhibitor of glycogen synthase kinase-3 (GSK-3 ) exhibiting an IC50 of approximately 30 nM Originally identified from a library of pyrrolopyrimidine-based compounds TWS119 binds GSK-3 with a Kd value around 126 nM By inhibiting GSK-3 activity TWS119 modulates downstream transcriptional events promoting neuronal differentiation in murine embryonic carcinoma (P19) and mouse embryonic stem cells through mechanisms distinct from classical Wnt signaling Due to this property TWS119 serves as a useful tool for research in neural differentiation and regenerative medicine
Apexbio Technology LLC Bupivacaine HCl 18010-40-7 10mM (in 1mL DMSO)
Bupivacaine Hydrochloride (CAS 18010-40-7) is an amino amide-type local anesthetic compound that functions primarily through blockade of voltage-gated sodium channels By preventing sodium ion influx in neuronal membranes it reduces action potential propagation resulting in reversible inhibition of nerve conduction Due to its relatively rapid onset paired with prolonged anesthetic duration bupivacaine hydrochloride is frequently utilized experimentally to investigate neuronal signaling pain mechanisms and local anesthetic pharmacology in biomedical research
Cayman Chemical L-MethIonIn SulfoxIde 5g
A sulfoxide-modified methionine; increases weight gain in weanling mice in the diet at 6.3, 12.6, and 18.9 mmol/g; levels are decreased in patients with vitiligo
Cayman Chemical L-MethIonIn SulfoxIde 1g
A sulfoxide-modified methionine; increases weight gain in weanling mice in the diet at 6.3, 12.6, and 18.9 mmol/g; levels are decreased in patients with vitiligo
Apexbio Technology LLC Maraviroc(Synonyms: Selzentry, Celsentri, UK-427857, MVC), 10mM (in 1mL DMSO), CAS: 376348-65-1.
Maraviroc (CAS 376348-65-1) is a potent selective antagonist of the chemokine receptor CCR5 CCR5 functions as a coreceptor expressed on immune cells and facilitates entry of certain HIV-1 virus strains (R5-tropic) By binding CCR5 maraviroc effectively blocks HIV-1 envelope protein gp120 anchoring and consequently prevents viral fusion and subsequent cell entry In cellular assays with CCR5-tropic HIV-1 maraviroc demonstrates substantial antiviral activity (IC50 approximately 2 0 nM) and efficiently inhibits gp120-CCR5 interaction Maraviroc serves as a valuable research tool to explore CCR5-mediated viral entry and HIV tropism dynamics
Apexbio Technology LLC Erlotinib Hydrochloride 183319-69-9 10mM (in 1mL DMSO)
Erlotinib hydrochloride (CAS 183319-69-9) is a small molecule inhibitor targeting the epidermal growth factor receptor (EGFR/HER-1) specifically blocking its tyrosine kinase activity By competitively inhibiting EGFR phosphorylation (IC50 2 nM) Erlotinib hydrochloride disrupts downstream signaling pathways involved in tumor cell proliferation apoptosis resistance migration and angiogenesis In vitro studies indicate this inhibitor induces G0/G1 cell cycle arrest and promotes apoptosis in cancer cell lines such as pancreatic (Bxpc-3 PANC-1) and hepatocellular carcinoma cells Erlotinib hydrochloride is widely studied in oncology research particularly in non-small cell lung cancer (NSCLC) and pancreatic cancer models
Apexbio Technology LLC Dapagliflozin(Synonyms: Farxiga, Forxiga, BMS-512148, AZD-1656, Dapagliflozin propanediol, Dapagliflozin hydrate), 10mM (in 1mL DMSO), CAS: 461432-26-8.
Dapagliflozin (CAS 461432-26-8) is a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2) an integral membrane protein primarily expressed in renal proximal tubules Acting via specific inhibition of SGLT2-mediated glucose reabsorption dapagliflozin facilitates urinary glucose excretion thereby regulating plasma glucose levels It exhibits a potent EC50 of approximately 1 1 nM for human SGLT2 and shows over 1 200-fold selectivity for hSGLT2 over hSGLT1 in vitro Preclinical studies demonstrate improved glucose tolerance enhanced urinary glucose excretion and reduction of hyperglycemia in diabetic animal models Thus dapagliflozin serves as an important investigational molecule for type 2 diabetes research
Apexbio Technology LLC (-)-JQ1 1268524-71-5 10mM (in 1mL DMSO)
(-)-JQ1 (CAS 1268524-71-5) is a stereoisomer of ( )-JQ1 designed as a negative control in bromodomain inhibition studies Unlike ( )-JQ1 a competitive BET bromodomain inhibitor known to displace BRD4 fusion oncoproteins from chromatin the (-)-enantiomer shows negligible interaction with tested bromodomains It exhibits minimal inhibitory activity against BRD4(1) with an IC50 of 10 000 nM Due to the lack of significant bromodomain binding (-)-JQ1 serves widely as an appropriate negative control compound in experiments investigating BET protein functions and related signaling
Apexbio Technology LLC Argatroban 74863-84-6 10mM (in 1mL DMSO)
Argatroban is a synthetic small-molecule inhibitor acting as a direct binder to thrombin s active site thereby blocking the thrombin-mediated conversion of fibrinogen into fibrin It competitively inhibits thrombin-induced platelet activation and blood clot formation exhibiting an inhibitory constant (Ki) of approximately 19 nM Due to its specificity and direct mechanism Argatroban is frequently employed in experimental research scenarios to investigate thrombin-dependent coagulation pathways platelet aggregation studies and antithrombotic effects in various in vitro assays and animal thrombosis models
Apexbio Technology LLC Calcipotriol 112965-21-6 10mM (in 1mL DMSO)
Calcipotriol is a synthetic analogue of vitamin D3 known to bind and activate the vitamin D receptor (VDR) Upon binding to VDR Calcipotriol modulates gene transcription involved in cellular differentiation and proliferation pathways This compound demonstrates regulatory effects on immune cells particularly T cells implicated in psoriasis pathogenesis and induces apoptosis in keratinocytes isolated from psoriasis lesions Calcipotriol also triggers autophagic processes in keratinocytes and HeLa cells in vitro Additionally it suppresses proliferation of various human tumor cell lines including HL-60 and MCF-7 in a concentration-dependent manner In research settings Calcipotriol is used to study differentiation proliferation and inflammatory responses of keratinocytes and immune-related cell types